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Milli-Mark™ Anti-CD19-FITC clone 6D5

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货号：FCMAB218F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC R FITC Monoclonal Antibody
Description
Catalogue Number FCMAB218F
Trade Name
  • Milli-Mark
Description Milli-Mark® Anti-CD19-FITC Antibody, clone 6D5
Alternate Names
  • B-lymphocyte antigen CD19
  • Differentiation antigen CD19
  • B4, Leu-12
Background Information CD19 is a member of the immunoglobulin superfamily which is expressed throughout B lymphocyte development, from early pro-B cell stages and into the mature B-cell stages during development. Also known as B4, CD19+ expression is found on mouse splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. CD19 plays an integral role in B lymphocyte development, B-cell activation, and in the maturation of memory B cells. Monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.
References
Product Information
Format FITC
Control
  • mouse splenocytes
Presentation Purified rat monoclonal IgG2ak conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
Application Detect CD19 using this Milli-Mark Anti-CD19-FITC Antibody, clone 6D5 validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Full-length murine CD19 cDNA cloned into a vector and expressed in K562 human erythroleukemia cells.
Clone 6D5
Host Rat
Specificity Antibody recognizes mouse CD19.
Isotype IgG2aκ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Cd19
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

SUBUNIT STRUCTURE: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402 By similarity.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

POST-TRANSLATIONAL MODIFICATION: Phosphorylated upon DNA damage, probably by ATM or ATR.

SEQUENCE SIMILARITIES: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Molecular Weight 60 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using mouse splenocytes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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