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Anti-Plexin-A1, clone 14A1.2 (mouse monoclonal)

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货号：MAB10419

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB10419
Description Anti-Plexin-A1 Antibody, clone 14A1.2
Alternate Names
  • Plexin-A1
  • Semaphorin receptor NOV
Background Information Although Plexin-A1 is a semaphorin receptor that is most commonly expressed in dendritic cells, it is most recognized as a proprioceptive sensory axon-specific receptor for Semaphorin-6C and Semaphorin-6D. Its most prominent role for sema6C/6D-plexinA1 signaling in sensory neuron development appears to be in the control of proprioceptive axon shaft position. In the absence of Plexin-A1 a breakdown of the exclusion of proprioceptive axon shafts from the superficial dorsal horn is observed, but without an impact on axon collateral trajectory. Plexin-A1 appears to be involved in T cell activation and may play a role in angiogenesis. A potential marker for dendritic cell maturity, Plexin-A1 has been found in the cytoplasm of the immature dendritic cells while localizing to the membranes of the mature ones.
References
Product Information
Format Purified
Control
  • HEK293 cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Plexin-A1 using this Anti-Plexin-A1 Antibody, clone 14A1.2 validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human Plexin-A1.
Clone 14A1.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PLXNA1
  • NOV
  • PLXN1
  • PLEXIN-A1
  • NOVP
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).

SIZE: 1896 amino acids; 211087 Da

SUBUNIT: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

TISSUE SPECIFICITY: Detected in fetal brain, lung, liver and kidney.

SIMILARITY: Belongs to the plexin family. & Contains 4 IPT/TIG domains. & Contains 1 Sema domain.
Molecular Weight ~211 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Plexin-A1 on 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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