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Anti-Anterior gradient protein 2 homolog, clone 7A10 (mouse monoclonal)

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货号：MABC48

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number MABC48
Description Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10
Alternate Names
  • anterior gradient homolog 2 (Xenopus laevis)
  • anterior gradient 2 homolog
  • protein disulfide isomerase family A, member 17
  • Secreted cement gland protein XAG-2 homolog
  • anterior gradient protein 2 homolog
  • secreted cement gland homolog
  • anterior gradient 2 homolog (Xenopus laevis)
Background Information Anterior gradient protein 2 homolog (AGR2) (also known as secreted cement gland protein XAG-2 homolog) is thought to be a metastasis-inducing protein in breast cancer models and may be used as a means of detecting the outcome of hormonally treated patients with breast cancer. AGR2 may also play an important role in intestinal mucus production. Recent researched has also linked AGR2 to metastasis. Lower levels of AGR expression in prostate cancer may be highly predictive of the reoccurrence of disease even after a prostatectomy.
References
Product Information
Format Purified
Control
  • MCF-7 cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10 is an antibody against Anterior gradient protein 2 homolog for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC on primary carcinomas (Barraclough, D., et al. (2009). Am J Pathol. 175:1848–1857).
Biological Information
Immunogen Linear peptide corresponding to a sequence unique to human Anterior gradient protein 2 homolog and not to human Anterior gradient protein 3 homolog.
Clone 7A10
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Specific for Anterior gradient protein 2 homolog and does not detect Anterior gradient protein 3 homolog.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • AGR2
  • GOB-4
  • AG2
  • HAG-2
  • XAG-2
  • PDIA17
  • AG-2
  • HPC8
  • hAG-2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.

SUBUNIT STRUCTURE: Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.

SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum (By similarity).

TISSUE SPECIFICTY: Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.

SEQUENCE SIMILARITIES: Belongs to the AGR family.
Molecular Weight ~18 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in MCF-7 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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