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Anti-FIH-1, clone FIH 162c (mouse monoclonal)

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货号：MABE102

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MABE1002
Description Anti-DIS3-like Exonuclease 2 Antibody, clone 9H2.1
Alternate Names
  • hDIS3L2
  • DIS3-like Exonuclease 2
  • DIS3L2
Background Information DIS3-like exonuclease 2 (UniProt Q8IYB7; also known as DIS3 mitotic control homolog-like 2, DIS3L2, Family with sequence similarity 6 member A, hDIS3L2) is encoded by the DIS3L2 (also known as FAM6A, PRLMNS) gene (Gene ID 129563) in human. Cytoplasmic mRNAs are regulated by degradations to ensure a fast and efficient control of the transcriptome at the post‐transcriptional level. The degradation process is initiated by deadenylation, followed by decapping, after which mRNA is accessible to digestion by the Xrn1 exonuclease in the 5′‐3′ direction or by the exosome complex in the 3′‐5′ direction. In yeast, the cytoplasmic exosome consists of nine inactive subunits (core ring structure) plus an active ribonuclease Rrp44/Dis3. Three Dis3 isoforms exist in human, DIS3, DIS3L, and DIS3L2. DIS3 is nuclear, and DIS3L and DIS3L2 are cytoplasmic. In addtion to mRNAs, DIS3L2 is also reported to mediate the degradtion of 3' uridylated let-7 precursor (pre-let-7) miRNA. Lin28 is a pluripotency factor expressed in stem cells and cancer cells, where it helps maintain the cells in an undifferentiated and proliferative state by preventing miRNA let-7 maturation. Lin28 binds to pre-let-7 and recruits 3′ terminal uridylyl transferase, which in turn marks pre-let-7 via 3′ oligouridylation for degradation by DIS3L2. Cellular DIS3L2 depletion causes mitotic abnormalities due to the deregulation of the expression of mitotic control proteins and DIS3L2 gene mutations are linked to the congenital overgrowth disease Perlman syndrome.
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-DIS3-like Exonuclease 2 Antibody, clone 9H2.1 is an antibody against DIS3-like Exonuclease 2 Antibody for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human DIS3-like Exonuclease 2.
Epitope Internal (N-terminal half)
Clone 9H2.1
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Expected to react with isoforms 1-4. Reactivity toward isoform 5 has not been determined.
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • DIS3L2
  • FAM6A
Purification Method Protein G Purified
UniProt Number
Molecular Weight ~100 kDa observed. 99.3 kDa (Isoform 1), 69.0 kDa (Isoform 2), 67.3 kDa (Isoform 3), 27.5 kDa (Isoform 4), 40.5 kDa (Isoform 5) calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected DIS3-like Exonuclease 2 in 10 µg of HepG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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