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Anti-SMAD4 (C-term), clone EP618Y, Rabbit Monoclonal

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货号：04-1033

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H IF, IP, WB M Purified Monoclonal Antibody
Description
Catalogue Number MAB1132
Replaces 04-1033
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Smad4 Antibody, clone SMD46
Alternate Names
  • DPC4
References
Product Information
Format Purified
Presentation 200 μg/ml antibody purified from ascites fluid by Protein G chromatography. Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
Applications
Application Anti-Smad4 Antibody, clone SMD46 is a Mouse Monoclonal Antibody for the detection of Smad4 & has been validated in IF, IP & WB.
Key Applications
  • Immunofluorescence
  • Immunoprecipitation
  • Western Blotting
Application Notes Immunofluorescence

Western Blotting: Ab 1μg/ml for 2hrs at room temperature

Immunoprecipitation (Use Protein G): Ab 2μg/mg protein lysate

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Purified recombinant DPC4 protein.
Clone SMD46
Host Mouse
Specificity Recognizes a protein of 60kDa, which is identified as DPC4 (also named SMAD4). Antibody is highly specific and shows no cross-reaction with the other closely related members of this family. The family of SMAD molecules comprises essential mediators of transforming growth factor beta (TGF-b) signaling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-beta superfamily gene transcription. At least two different members, Smad2 and Smad4/DPC4, have been implicated in human cancer and appear to have tumor-suppressor functions whose inactivation may play an important role in the histogenesis of pancreatic and colorectal malignancy and possibly other human cancers as well.
Isotype IgG1
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • SMAD4
  • DPC4
  • hSMAD4
  • MADH4
  • JIP
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13485 # Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor.
SIZE: 552 amino acids; 60439 Da
SUBUNIT: May form trimers with receptor-regulated SMAD (R-SMAD). Interacts with ATF2, COPS5, DACH1, MSG1, SKI and TRIM33. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD.
DISEASE: SwissProt: Q13485 # Defects in SMAD4 are a cause of pancreatic carcinoma [MIM:260350]. & Defects in SMAD4 are a cause of juvenile polyposis syndrome (JPS) [MIM:174900]; also known as juvenile intestinal polyposis (JIP). JPS is an autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. & Defects in SMAD4 are a cause of juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome (JP/HHT) [MIM:175050]. JP/HHT syndrome phenotype consists of the coexistence of juvenile polyposis (JIP) and hereditary hemorrhagic telangiectasia (HHT) [MIM:187300] in a single individual. JIP and HHT are autosomal dominant disorders with distinct and non- overlapping clinical features. The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in SMAD4 or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG or ACVRL1. All four genes encode proteins involved in the transforming-growth-factor- signaling pathway. Although there are reports of patients and families with phenotypes of both disorders combined, the genetic aetiology of this association is unknown. & Defects in SMAD4 may be a cause of colorectal cancer (CRC) [MIM:114500].
SIMILARITY: SwissProt: Q13485 ## Belongs to the dwarfin/SMAD family. & Contains 1 MH1 (MAD homology 1) domain. & Contains 1 MH2 (MAD homology 2) domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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