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Anti-Neuregulin-1, clone D11 (mouse monoclonal)

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货号：MABN42

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M WB, ICC M Purified Monoclonal Antibody
Description
Catalogue Number MABN42
Description Anti-Neuregulin-1 Antibody, clone D11
Alternate Names
  • neuregulin 1
  • sensory and motor neuron derived factor
  • neu differentiation factor
  • pro-neuregulin-1, membrane-bound isoform
  • heregulin, alpha (45kD, ERBB2 p185-activator)
  • heregulin, alpha (45kD, ERBB2 p185-activator)
  • glial growth factor
Background Information The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003).
References
Product Information
Format Purified
Control
  • Mouse brain microsomal tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Neuregulin-1 using this Anti-Neuregulin-1 Antibody, clone D11 validated for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.)
Biological Information
Immunogen His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain.
Epitope Extracellular domain
Clone D11
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Neuregulin-1 at the extracellular domain.
Isotype IgG1κ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GGF
  • NDF
  • GGF2
  • HGL
  • MST131
  • HRGA
  • HRG
  • HRG1
  • SMDF
  • ARIA
  • pro-NRG1
  • MSTP131
  • Pro-NRG1
Purification Method Protein G
UniProt Number
Molecular Weight ~29 kDa observed. This target has been shown to undergo differential splicing during development into ~30 different isoforms.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse brain microsomal tissue lysate.

Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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