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Anti-HDAC9, clone LH/JC2 (rat monoclonal IgM)

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货号：05-897

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC R Purified Monoclonal Antibody
Description
Catalogue Number 05-897
Replaces MABE562
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-HDAC9 Antibody, clone LH/JC2
References
Product Information
Format Purified
Applications
Application Detect HDAC9 also known as histone deacetylase 9 with Anti-HDAC9 Antibody, clone LH/JC2 (Rat Monoclonal Antibody), that has been demonstrated to work in WB, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen synthetic peptide corresponding to amino acids 1046-1060 of human HDAC9 isoform 5
Clone clone LH/JC2
Host Rat
Specificity HDAC9
Isotype IgM
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Gene Symbol
  • HDAC9
  • HDAC9FL
  • MITR
  • HD9
  • HDRP
  • HDAC9B
  • KIAA0744
  • DKFZp779K1053
  • HDAC
  • HD7B
  • HD7
  • HDAC7B
  • HDAC7
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UKV0 # Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter.
SIZE: 1011 amino acids; 111297 Da
SUBUNIT: Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3- binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. & Sumoylated.
DISEASE: SwissProt: Q9UKV0 # A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
SIMILARITY: SwissProt: Q9UKV0 ## Belongs to the histone deacetylase family. Type 2 subfamily.
Molecular Weight 160kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot with RIPA lysates from HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C from date of shipment
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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