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Hck, activated, 10 ug

市场价：: 0.00

促销价：: ¥0.00

货号：14-843

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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Replacement Information

Description
Catalogue Number	14-843
Brand Family	Upstate
Trade Name	Upstate
Description	Hck Protein, activated, 10 µg
Overview	N-terminal 6His-tagged, recombinant, human Hck, amino acids 230–497

References

Product Information
Presentation	50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol, 5mM β-glycerophosphate, 1mM Na3VO4. Frozen solution.

Applications
Application	activated, N-terminal 6His-tagged, recombinant, human Hck, amino acids 230–497, for use in Kinase Assays.
Key Applications	Kinase Assay
Application Notes	Auto-activated on column by incubating with Mg/ATP, excess ATP and MgAc removed by multiple column wash steps.

Biological Information
Source	Expressed by baculovirus in Sf21 insect cells
Specific Activity	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number	NM_002110.2
Entrez Gene Summary	The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
Gene Symbol	HCK p59-HCK/p60-HCK JTK9
Protein Target	Hck
Purification Method	Ni²⁺/NTA-agarose
Target Sub-Family	TK
UniProt Number	P08631
UniProt Summary	FUNCTION: SwissProt: P08631 # May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils. SIZE: 526 amino acids; 59600 Da SUBUNIT: May bind to HIV-1 Nef and VIF through its SH3 domain. This interaction would stimulates its tyrosine-kinase activity. SUBCELLULAR LOCATION: Isoform p59-HCK: Membrane; Lipid-anchor. & Isoform p60-HCK: Membrane; Lipid-anchor. Cytoplasm. TISSUE SPECIFICITY: Expressed predominantly in cells of the myeloid and B-lymphoid lineages. DOMAIN: SwissProt: P08631 The SH3 domain mediates binding to HIV-1 Nef. PTM: Isoform p59-HCK contains a N-myristoyl glycine at position 3 (By similarity). Isoform p59-HCK contains a S-palmitoyl cysteine at position 3 (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight	34.1kDa

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	6 months at -70°C

Packaging Information
Material Size	10 µg
Material Package	Also available in 250 µg size --call for pricing and availability and reference catalog number 14-843M when ordering the 250 µg size.

Transport Information

Supplemental Information

Specifications

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