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ANTI PPKA, RII (SER96) 100UG

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货号：06-704

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABT58
Replaces 06-704
Description Anti-phospho PKA-RII (Ser96) Antibody
Alternate Names
  • PRKAR2A
  • protein kinase
  • cAMP-dependent, regulatory, type II, alpha
Background Information cAMP-dependent protein kinase type II-alpha regulatory subunit (PKA-RIIα) is an enzymatic protein belonging to the cAMP-dependent kinase regulatory chain family, a group of regulatory proteins involved in the PKA signaling pathway. This pathway has been shown to have regulatory roles in development, growth, and mortality of various organisms. PKA-RIIα is a subunit of the PKA type II regulatory chain, one of two PKA isoforms, and is involved in the regulation of membrane interactions through its binding to anchoring proteins, such as MAP2 kinase. Before its activation with cAMP, the enzyme is comprised of two catalytic chains and two regulatory chains, which split into two catalytic monomers and one regulatory dimmer after interacting with cAMP.
References
Product Information
Format Affinity Purified
Control
  • Forskolin untreated and treated PC12 cell lysates
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
Applications
Application This Anti-phospho PKA-RII (Ser96) Antibody is validated for use in WB for the detection of phospho PKA-RII (Ser96).
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to mouse PKA-RIIalpha phosphorylated at Ser96.
Epitope Phosphorylated Ser96 of PKA-RIIalpha
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody recognizes PKA-RIIalpha when phosphorylated at Ser96.
Species Reactivity
  • Human
  • Rat
  • Mouse
Species Reactivity Note Demonstrated to react with human and rat. Predicted to react with mouse based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PRKAR2A
  • PKR2
  • PRKAR2
Modifications
  • Phosphorylation
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

SUBUNIT STRUCTURE: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4. Interacts with CBFA2T3 (by similarity).

TISSUE SPECIFICTY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

PTM: Phosphorylated by the activated catalytic chain.

SEQUENCE SIMILARITIES: Belongs to the cAMP-dependent kinase regulatory chain family.

Contains 2 cyclic nucleotide-binding domains.
Molecular Weight ~ 51 kDa MW observed. The specificity of the target was shown by Lambda phosphatase treatment.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in Forskolin untreated and treated PC12 cell lysates.

Western Blot Analysis: 1 µg/mL of the antibody detected PKA-RIIalpha (Ser96) in 10 µg of Forskolin untreated and treated PC12 cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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