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Ms X Cytokeratin 10

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货号：MAB3230

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
Ca, H, M, R FC, WB, ICC, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB3230
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cytokeratin 10 Antibody, clone RKSE60
Background Information Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8, The individual cytokeratin polypeptides are designated 1-20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies.
References
Product Information
Format Purified
Presentation Liquid in buffer with 0.1% sodium azide.
Applications
Application Anti-Cytokeratin 10 Antibody, clone RKSE60 detects level of Cytokeratin 10 & has been published & validated for use in FC, WB, IC, IH.
Key Applications
  • Flow Cytometry
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Western blot

Immunohistochemistry on frozen tissue sections.

Immunocytochemistry

Flow cytometry

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Cytoskeletal preparation from human squamous keratinizing epithelium.
Clone RKSE60
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity Cytokeratin 10. MAB3230 reacts with keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas. For the recognition of keratinizing cells in squamous cell carcinomas from epidermis, lung, bladder, cervix, esophagus etc. The antibody reacts only with suprabasal cells of the epidermis and not with basal cells.
Isotype IgG1
Species Reactivity
  • Canine
  • Human
  • Mouse
  • Rat
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.
Gene Symbol
  • KRT10
  • K10
  • CK-10
  • Keratin-10
  • Cytokeratin-10
  • KPP
  • CK10
UniProt Number
UniProt Summary SIZE: 593 amino acids; 59511 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.
TISSUE SPECIFICITY: Seen in all suprabasal cell layers including stratum corneum.
DISEASE: SwissProt: P13645 # Defects in KRT10 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]; also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. & Defects in KRT10 are a cause of annular epidermolytic ichthyosis (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens. & Defects in KRT10 are a cause of epidermal nevus epidermolytic hyperkeratotic type [MIM:600648]. Epidermal nevi affect about 1 in 1,000 people. They appear at or shortly after birth as localized lines of epidermal thickening. The extent of skin involvement varies widely.
SIMILARITY: SwissProt: P13645 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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