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Anti-LAMP-2, clone M3/84 (rat monoclonal)

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货号：MABC24

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC, IP, IHC, IF R Purified Monoclonal Antibody
Description
Catalogue Number MABC24
Description Anti-LAMP-2 Antibody, clone M3/84
Alternate Names
  • lysosomal-associated membrane protein 2
  • CD107 antigen-like family member B
  • CD107b antigen
Background Information Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy.
References
Product Information
Format Purified
Control
  • NIH/3T3 cells
Presentation Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-LAMP-2 Antibody, clone M3/84 is validated for use in FC, IP, IH, IF for the detection of LAMP-2.
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
  • Immunohistochemistry
  • Immunofluorescence
Application Notes Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Springer, T., et al. (1981). The Journal of Biological Chemistry. 256(8):3833-3839).

Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Springer, T., et al. (1983). Am J Pathol. 111(1):112-24).

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Deng. Y., et al. (1998). Proc. Nati. Acad. Sci. USA. 85:3860-3864).
Biological Information
Immunogen Murine macrophage membranes
Clone M3/84
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rat
Isotype IgG1κ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD107b
  • LAMPB
  • LGP110
  • LAMP-2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.

PTM: O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans (By similarity).

SEQUENCE SIMILARITIES: Belongs to the LAMP family.
Molecular Weight 46 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in NIH/3T3 cells.

Flow Cytometry Analysis: 10 µg of this antibody detected LAMP-2 in NIH/3T3 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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