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Anti-GCLM, clone CPTC-GCLM-3 (mouse monoclonal)

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货号：MABS32

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABS32
Description Anti-GCLM Antibody, clone CPTC-GCLM-3
Alternate Names
  • glutamate-cysteine ligase, modifier subunit
  • GCS light chain
  • glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
  • Gamma-ECS regulatory subunit
  • GSC light chain
  • Glutamate--cysteine ligase modifier subunit
  • glutamate--cysteine ligase regulatory subunit
  • Gamma-glutamylcysteine synthetase regulatory subunit
  • glutamate-cysteine ligase regulatory protein
Background Information Glutamate-cysteine ligase modifier subunit (GCLM) is one of two parts of glutamate-cysteine ligase (GCL). GCL is responsible for catalyzing the rate-limiting step in the synthesis of cellular antioxidant glutathione (GSH). With the introduction of oxidative stress, GCLM was modified from its monomeric form to a holoenzyme. There is evidence that a functional mutation in GCLM could leave a patient with a predisposition to schizophrenia.
References
Product Information
Format Purified
Control
  • HeLa cell lysate
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-GCLM Antibody, clone CPTC-GCLM-3 is validated for use in WB, IH for the detection of GCLM.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Biological Information
Immunogen Full length recombinant protein corresponding to human GCLM.

Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Clone CPTC-GCLM-3
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq].
Gene Symbol
  • GLCLR
  • GCLM3
Purification Method Protein G
UniProt Number
UniProt Summary PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.

SUBUNIT STRUCTURE: Heterodimer of a catalytic heavy chain and a regulatory light chain.

TISSUE SPECIFICTY: In all tissues examined. Highest levels in skeletal muscle.

SEQUENCE SIMILARITIES: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
Molecular Weight ~ 31 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected GCLM on 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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