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Anti-TLE1 (rabbit polyclonal)

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货号：ABD119

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number ABD119
Description Anti-TLE1 Antibody
Alternate Names
  • Transducin-like enhancer protein 1
  • E(Sp1) homolog
  • Enhancer of split groucho-like protein 1
  • ESG1
Background Information Transducin-like enhancer protein 1 (UniProt Q04724; also known as E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1) is encoded by the TLE1 gene (Gene ID 7088) in human. TLE proteins interact with HDACs as well as deacetylated histone tails and play an important role in transcription regulation in several signaling pathways, including Ras, Notch, and Wnt. TLE proteins contain a conserved N-terminal glutamine-rich (Q) domain (a.a. 1-131 of TLE1) that mediates TLEs tetramerization as well as TCF/LEF proteins binding, and is essential for chromatin oligomerization. This is followed by a variable central domain sub-divided into a glycine-prolin-rich (GP) region (a.a. 132-199 of TLE1), the CcN (protein kinase CK2/cell cycle-dependent kinase 2/nuclear localization sequence) domain (a.a. 200-268), a serine-proline-rich (SP) region (a.a. 200-268 and 269-450 of TLE1), and a C-terminal WD40 domain with 6 WD repeats (a.a. 470-767 of TLE1) that interact with multiple transcription factors. The GP region binds directly to HDAC1, the CcN region contains consensus CK2 and Cdc2 phosphorylation sites that are modified in a cell cycle-dependent manner, the SP region is phosphorylated by the Ser/Thr kinases HIPK2 and MAPK, which appear to negatively regulate transcription repression activity, and may also interact with basic helix-loop-helix transcription factors. The C-terminal WD40 domain is essential for chromatin condensation and, together with SP, interacts with bHLH proteins.
References
Product Information
Format Affinity Purified
Presentation Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-TLE1 Antibody is validated for use in Western Blotting, Immunocytochemistry for the detection of TLE1.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Immunocytochemistry Analysis: 1 µg/mL from a representative lot detected TLE1 in HeLa cells and H9 human stem cells.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to a sequence within the CcN domain of human TLE1.
Epitope CcN domain.
Concentration Please refer to lot specific datasheet.
Host Rabbit
Specificity This polyclonal antibody targets the CcN (protein kinase CK2/cell cycle-dependent kinase 2/nuclear localization sequence) domain of TLE1 and stained cell nuclei by fluorescent immunocytochemistry.
Species Reactivity
  • Human
Species Reactivity Note Human. Predicted to react with Mouse based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TLE1
Purification Method Affinity purified.
UniProt Number
Molecular Weight ~90 kDa observed. 83.20 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in H9 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antiobdy detected TLE1 in 10 µg of H9 human stem cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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