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Anti-LIBS2 epitope (Integrin beta3 subunit), clone ab62 (mouse monoclonal)

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货号：MABT27

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, FC M Purified Monoclonal Antibody
Description
Catalogue Number MABT27
Description Anti-LIBS2 epitope (Integrin beta3 subunit) Antibody, clone ab62
Alternate Names
  • LIBS2 domain, Integrin, Integrin alphaVbeta3, LIBS2 epitiope
Background Information The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue.
Clone Ab62 is a monoclonal antibody that specifically recognizes the LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit (Wiberzbicka-Patynowski, I., et al. (1999). JBC. 274(53):37809-37814).
References
Product Information
Format Purified
Control
  • Human platelets cell lysate
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-LIBS2 epitope (Integrin beta3 subunit) Antibody, clone ab62 is an antibody against LIBS2 epitope (Integrin beta3 subunit) for use in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application Notes Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Ginsberg, M., et al. (1990). Blood. 76:2017-2023.)
Biological Information
Immunogen Human GPIIa-IIIb purified from platelets
Epitope LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit of integrins.
Clone ab62
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes the LIBS2 epitope in the C-terminal region of the extracellular domain of the beta3 subunit of integrins.
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Gene Symbol
  • LIBS2
Purification Method Protein G Purified
Molecular Weight ~110 kDa observed in human platelets.
Other MW bands may vary or may be observed depending on lysate used and if the LIBS2 epitope is present in other proteins.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human platelets cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected LIBS2 domain of integrin beta3 subunit in 10 µg of human platelets cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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