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Anti-Annexin A1, clone CPTC-ANXA1-2 (mouse monoclonal)

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货号：MABS45

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABS45
Description Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2
Alternate Names
  • annexin A1
  • chromobindin-9
  • annexin I (lipocortin I)
  • Lipocortin I
  • calpactin-2
  • Calpactin II
  • annexin-1
  • Phospholipase A2 inhibitory protein
  • Annexin I
  • Calpactin-2
  • Annexin-13
  • Chromobindin-9
Background Information Annexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.
References
Product Information
Format Purified
Control
  • K562 cell lysate
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-ANXA1-2)
Biological Information
Immunogen Full length recombinant protein corresponding to human Annexin A1.

Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program
Clone CPTC-ANXA1-2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq].
Gene Symbol
  • ANXA1
  • LPC1
  • ANX1
  • p35
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

SUBUNIT STRUCTURE: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity).

SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection › cilium (By similarity). Basolateral cell membrane (By similarity). Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).

DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.

PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.

SEQUENCE SIMILARITIES: Belongs to the annexin family.

Contains 4 annexin repeats.
Molecular Weight ~ 39 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in K562 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Annexin A1 on 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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