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Anti-Integrin beta-2 (CD18), clone M18/2 (rat monoclonal)

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货号：MABT42

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC, IP R Purified Monoclonal Antibody
Description
Catalogue Number MABT42
Description Anti-Integrin beta-2 (CD18) Antibody, clone M18/2
Alternate Names
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
  • integrin beta chain, beta 2
  • complement receptor C3 beta-subunit
  • leukocyte cell adhesion molecule CD18
  • integrin beta-2
  • Complement receptor C3 subunit beta
  • Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
  • CD18 antigen
  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1
  • macrophage antigen 1 (mac-1) beta subunit)
  • cell surface adhesion glycoprotein (LFA-1,CR3,P150,959 beta subunit precursor)
  • cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
Background Information Integrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma.
References
Product Information
Format Purified
Control
  • Mouse EL4 cells
Presentation Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).
Key Applications
  • Flow Cytometry
  • Immunoprecipitation
Application Notes Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).

Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466).
Biological Information
Immunogen Whole B10 mouse spleen cells enriched with T-cells.
Clone clone M18/2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rat
Isotype IgG2aκ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CD18
  • LFA-1
  • MAC-1
  • CD18
  • MF17
  • MFI7
  • LCAMB
  • LAD2
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.

Contains 1 VWFA domain.
Molecular Weight 85 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in mouse EL4 cells.

Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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