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Anti-Siglec-8, clone 7C9 (mouse monoclonal)

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货号：04-1473

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H FC M Purified Monoclonal Antibody
Description
Catalogue Number 04-1473
Description Anti-Siglec-8 Antibody, clone 7C9
Alternate Names
  • sialic acid binding Ig-like lectin 8
  • sialic acid-binding Ig-like lectin 8
  • CD329 antigen
  • Sialoadhesin family member 2
Background Information Siglec-8 is a sialic acid-binding immunoglobulin-like lectin that is mostly expressed in eosinophils. Siglec-8 is thought to contain three immunoglobulin-like domains, a transmembrane region, and a 47 amino acid cytoplasmic tail. Siglec-8 is expressed on COS cells and is able to intercede sialic acid-dependent binding to erythrocytes and sialoglycoconjugates. Combining Siglec-8 with certain antibodies is thought to promote human eosinophil apoptosis.
References
Product Information
Format Purified
Control
  • Human PBMC's
Presentation Purified mouse monoclonal IgGκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Siglec-8 using this Anti-Siglec-8 Antibody, clone 7C9 validated for use in FC.
Key Applications
  • Flow Cytometry
Application Notes ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Floyd, H., et al. (2000). Journal of Biological Chemistry. 275(2):861–866).

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Floyd, H., et al. (2000). Journal of Biological Chemistry. 275(2):861–866).

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Floyd, H., et al. (2000). Journal of Biological Chemistry. 275(2):861–866).
Biological Information
Immunogen Extracellular region of human recombinant Siglec-8 cleaved with Factor Xa.
Clone 7C9
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motihttp://47.97.66.201:8088/statics an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM].
Gene Symbol
  • SIGLEC8
  • CDw329
  • SAF2
  • SAF-2
  • SIGLEC8L
  • SIGLEC-8
  • Siglec-8
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

TISSUE SPECIFICTY: Expressed specifically on eosinophils.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Molecular Weight 54 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Flow Cytometry in human PBMC's.

Flow Cytometry Analysis: 2 µg of this antibody detected Siglec-8 in human PBMC's.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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