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Anti-NLRX1 (NOD9) (rabbit polyclonal)

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货号：06-1342

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Ox WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 06-1342
Description Anti-NLRX1 (NOD9) Antibody
Alternate Names
  • Nucleotide-binding oligomerization domain protein 26
  • Nucleotide-binding oligomerization domain protein 5
  • Nucleotide-binding oligomerization domain protein 9
  • NLR family member X1
  • NLR family, X12
  • Nucleotide-binding oligomerization domain protein 9
  • Caterpiller protein 11.3
  • NOD-like receptor X1
Background Information NLR family member X1 (NLRX1) belongs to the Nod-like receptor (NLR) family of proteins, a group of proteins characterized by their highly conserved nucleotide binding domain (NBD) and their leucine-rich-repeats (LRR). NLRX1 is the only member of this family localized to mitochondria, where it plays a role in antiviral signaling by blocking virus-induced interaction of RLH-MAVS, serving as a negative regulator of the antiviral responses mediated by MAVS. It also serves to up-regulate NF-Kappa-B and JNK-dependent signaling cascades as its overexpression induces reactive oxygen species (ROS). NLRX1 has been observed in high quantities within the heart, mammary gland, and muscle tissues. It has also been observed at the protein level in various cell lines including; JURKAT, HeLa, HL60, RAJI, THP-1, and 293T.
References
Product Information
Format Affinity Purified
Control
  • PC3 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect NLRX1 (NOD9) using this Anti-NLRX1 (NOD9) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human NLRX1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Ox
Species Reactivity Note Demonstrated to react with human, mouse, and rat.
Predicted to react with ox based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq].
Gene Symbol
  • nlrx1
  • NOD5
  • NOD26
  • NOD9
  • CLR11.3
  • DLNB26
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.

SUBUNIT STRUCTURE: Interacts with MAVS.

SUBCELLULAR LOCATION: Mitochondrion outer membrane

TISSUE SPECIFICTY: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).

SEQUENCE SIMILARITIES: Belongs to the NLRP family.

Contains 4 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.

SEQUENCCE CAUTION: The sequence BAB15075.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAG51714.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG51714.1 differs from that shown. Reason: Erroneous termination at position 951. Translated as Trp.
Molecular Weight ~115/112 kDa observed.
Doublet observed may be due to incomplete maturation by mitochondrial processing peptidases (MPPs). MPP maturation is common process for many proteins of the mitochondrial matrix and some proteins of the inner membrane space (Arnoult, D., et al. (2009). Journal of Cell Science 122:3161-3168).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC3 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected NLRX1 in 10 µg of PC3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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