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Milli-Mark™ Anti-mouse Interleukin-4-PE clone 11B11

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货号：FCMAB245P

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC R Phycoerythrin Monoclonal Antibody
Description
Catalogue Number FCMAB245P
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-mouse Interleukin-4-PE Antibody, clone 11B11
Alternate Names
  • B cell growth factor 1
  • B-cell stimulatory factor 1
  • B_cell stimulatory factor 1
  • Lymphocyte stimulatory factor 1
  • interleukin 4
Background Information Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
References
Product Information
Format Phycoerythrin
Control
  • Mick2 cells
Presentation Purified rat monoclonal IgG1κ conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
Application Milli-Mark Anti-mouse Interleukin-4-PE Antibody, clone 11B11 detects level of mouse Interleukin-4 & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Recombinant protein corresponding to mouse IL-4.
Clone 11B11
Host Rat
Specificity Antibody recognizes IL-4.
Isotype IgG1κ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • IL4
  • Binetrakin
  • Pitrakinra
  • BSF1
  • BSF-1
  • IL-4
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

SUBCELLULAR LOCATION: Secreted.

SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
Molecular Weight 15 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using Mick2 cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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