Anti-KLF5 (Krüppel-like factor 5) (rabbit polyclonal) - 炼石商城

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Anti-KLF5 (Krüppel-like factor 5) (rabbit polyclonal)

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货号：09-822

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	WB, ChIP	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	09-822
Description	Anti-KLF5 (Krüppel-like factor 5) Antibody
Alternate Names	BTE-binding protein 2 Basic transcription element-binding protein 2 Colon krueppel-like factor GC box binding protein 2 GC-box-binding protein 2 Intestinal-enriched krueppel-like factor Kruppel-like factor 5 Kruppel-like factor 5 (intestinal) Transcription factor BTEB2 basic transcription element binding protein 2 colon kruppel-like factor intestinal-enriched kruppel-like factor
Background Information	Krüppel-like factors (KLFs) are zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation.

References

Product Information
Format	Serum
Control	Mouse embryonic stem cell chromatin extract
Presentation	Rabbit polyclonal serum containing 0.05% sodium azide.

Applications
Application	Anti-KLF5 (Krüppel-like factor 5) Antibody is a Rabbit Polyclonal Antibody for detection of KLF5 (Krüppel-like factor 5) also known as Krüppel-like factor 5 & has been validated in WB.
Key Applications	Western Blotting Chromatin Immunoprecipitation (ChIP)
Application Notes	Chromatin Immunoprecipitation Analysis (ChIP): A representative lot was used by an independent laboratory in ChIP. (Ng Huck Hui, Genome Institute of Singapore)

Biological Information
Immunogen	Recombinant protein corresponding to mouse Krüppel-like factor 5 at the N-terminus.
Epitope	N-terminus
Host	Rabbit
Specificity	This antibody recognizes Krüppel-like factor 5 at the N-terminus.
Species Reactivity	Mouse
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_033899
Gene Symbol	KLF5 CKLF BTEB2 IKLF
Purification Method	Unpurified
UniProt Number	Q9Z0Z7
UniProt Summary	FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. SUBUNIT STRUCTURE: Interacts with WWP1 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Highest expression in digestive track. PTM: Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. SEQUENCE SIMILARITIES: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Molecular Weight	~55 kDa observed. An uncharacterized band appears at ~30 kDa.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blot in mouse embryonic stem cell chromatin extract. Western Blot Analysis: 1:2,000 dilution of this antibody detected Krüppel-like factor 5 on 10 µg of mouse embryonic stem cell chromatin extract.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

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