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Milli-Mark™ Anti-mouse CD45R (B220)-FITC clone RA3-3A1/6.1

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货号：FCMAB228F

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M FC R FITC Monoclonal Antibody
Description
Catalogue Number FCMAB228F
Trade Name
  • Milli-Mark
Description Milli-Mark™ Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1
Alternate Names
  • Receptor-type tyrosine-protein phosphatase C
  • Leukocyte common antigen
  • L-CA
  • Lymphocyte antigen 5
  • Ly-5
  • T200
Background Information The interleukin-2 receptors consist of three polypeptides (α, β, γ), which in different combinations bind IL-2 (Ishii, 1995). The 55 kDa α-chain is called CD25. CD25 is strongly expressed on the surface of activated T cells (Uchiyama, 1981), and is also expressed on B cells stimulated with anti-IgM antibody, and on monocytes/macrophages stimulated with lipopolysaccharide (Sugamura, 1997). In normal peripheral blood a variable expression on lymphoid cells (about 3-25%) is observed. The specificity of Anti-CD25, ACT-1, is identical to that of CD25-clustered antibodies (Schwarting, 1987; Aziz, 1996).
References
Product Information
Format FITC
Control
  • Mouse splenocytes
Presentation Purified rat monoclonal IgM conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
Application Milli-Mark Anti-mouse CD45R (B220)-FITC Antibody, clone RA3-3A1/6.1 is an antibody against mouse CD45R (B220) for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Animals were immunized with the mouse cell line RAW 112. Spleen cells were fused with the S194/5.XX0.BU.1 myeloma.
Clone RA3-3A1/6.1
Host Rat
Specificity Antibody recognizes CD45 isoform 1 also known as B220.
Isotype IgMκ
Species Reactivity
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Ptprc
  • Ly-5
Purification Method Ion Exchange
UniProt Number
UniProt Summary FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN By similarity.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

SUBUNIT STRUCTURE: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.

DEVELOPMENTAL STAGE: Expression is restricted to the hematopoietic compartment of development.

DOMAIN: The first PTPase domain interacts with SKAP1

POST-TRANSLATIONAL MODIFICATION: Heavily N- and O-glycosylated.

SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.
Molecular Weight 144 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by flow cytometry using mouse splenocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
Packaging Information
Material Size 100 tests
Transport Information
Supplemental Information
Specifications

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