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Histamine Receptor 4 Control Peptide

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货号：AG217

品牌：Millipore 密理博

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Description
Catalogue Number AG217
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Histamine Receptor 4, control peptide for AB5663P
Overview Synthetic 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4.
References
Product Information
Presentation Liquid in PBS containing 0.1% sodium azide.
Applications
Key Applications
  • Cell Function Assay
Application Notes For use in blocking the reactivity of AB5663P.

Optimal working dilution must be determined by the end user.
Biological Information
Concentration 1.0 mg/mL
Entrez Gene Number
Entrez Gene Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
Gene Symbol
  • HRH4
  • MGC133027
  • GPCR105
  • HH4R
  • GPRv53
  • H4R
  • H4
  • AXOR35
  • SP9144
  • BG26
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
SIZE: 390 amino acids; 44496 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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