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Anti-Prohormone Convertase PC1/PC3 (rabbit polyclonal)

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货号：AB10553

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, ICC, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB10553
Description Anti-Prohormone Convertase PC1/PC3 Antibody
Alternate Names
  • NEC 1
  • Prohormone convertase 1
  • Proprotein convertase 1
  • neuroendocrine convertase 1
  • prohormone convertase 3
  • proprotein convertase subtilisin/kexin type 1
Background Information The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
References
Product Information
Format Affinity Purified
Control
  • Mouse adrenal gland tissue lysate
Presentation Rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Prohormone Convertase PC1/PC3 Antibody is an antibody against Prohormone Convertase PC1/PC3 for use in WB, IC, IH.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application Notes Immunocytochemistry Analysis: 1: 500 dilution from a previous lot detected Prohormone Convertase PC1/PC3 in HeLa, C2C12, NIH/3T3 cell lysates.
Biological Information
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated linear peptide within human Prohormone Convertase PC1/PC3.
Epitope Mature Chain
Host Rabbit
Specificity This antibody recognizes Prohormone Convertase PC1/PC3.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with human, mouse and rat. Predicted to react with pig based on sequence homology. Ape, dog, and rat (97%). Bovine (95%).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • BMIQ12
  • EC 3.4.21.93
  • NEC1
  • PC1
  • PC3
  • SPC3
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
CATALYTIC ACTIVITY: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
COFACTOR: Calcium.
SUBCELLULAR LOCATION: Cytoplasmic vesicle › secretory vesicle. Note: Localized in the secretion granules.
POLYMORPHISM: Genetic variations in PCSK1 define the body mass index quantitative trait locus 12 (BMIQ12) [MIM:612362]. Variance in body mass index is a susceptibility factor for obesity.
INVOLVEMENT IN DISEASE: Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
SEQUENCE SIMILARITIES: Belongs to the peptidase S8 family. Furin subfamily.
Molecular Weight Observed at 95 KDa because of multiple glycosylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse adrenal gland tissue lysate.
Western Blot Analysis: : 0.5 µg/mL of this lot detected Prohormone Convertase PC1/PC3 on 10 µg of mouse adrenal gland tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain refrigerated at 2-8°C for up to 12 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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