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Anti-Chloride intracellular channel protein (CLIC1), clone CPTC-CLIC1-1 (mouse monoclonal)

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货号：MABN46

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MABN46
Description Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
Alternate Names
  • chloride intracellular channel 1
  • Chloride channel ABP
  • RNCC protein
  • Nuclear chloride ion channel 27
  • nuclear chloride ion channel protein
  • Regulatory nuclear chloride ion channel protein
  • chloride intracellular channel protein 1
Background Information Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression.
References
Product Information
Format Purified
Control
  • Human liver tissue lysate
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 detects level of Chloride intracellular channel protein (CLIC1) & has been published & validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-CLIC1-2)
Biological Information
Immunogen Full length recombinant protein corresponding to human CLIC1.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Clone CPTC-CLIC1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq].
Gene Symbol
  • CLIC1
  • G6
  • NCC27
  • p64CLCP
  • hRNCC
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

SUBUNIT STRUCTURE: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.

SUBCELLULAR LOCATION: Nucleus. Nucleus membrane; Single-pass membrane protein Probable. Cytoplasm. Cell membrane; Single-pass membrane protein Probable. Note: Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

TISSUE SPECIFICTY: Expression is prominent in heart, placenta, liver, kidney and pancreas.

DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

PTM: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.

MISCELLANEOUS: The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals.

SEQUENCE SIMILARITIES: Belongs to the chloride channel CLIC family.

Contains 1 GST C-terminal domain.
Molecular Weight ~27 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.25 µg/mL of this antibody detected CLIC1 on 10 µg of human liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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