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Anti-Aldose reductase, clone CPOTC-AKR1B1-1 (mouse monoclonal)

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货号：MABS18

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MABS18
Description Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1
Alternate Names
  • aldo-keto reductase family 1, member B1 (aldose reductase)
  • aldose reductase
  • Aldo-keto reductase family 1 member B1
  • low Km aldose reductase
  • Lii5-2 CTCL tumor antigen
  • aldehyde reductase 1
  • Aldehyde reductase
Background Information Aldose reductase (AR) is s a therapeutic target for treatment of long-term obstacles of diabetes. AR has also been shown to be a component of antioxidant defense and of stress-induced signaling. It is an important component of cellular redox state and regulation of signaling cascades that may play a part in regulating cytotoxic occurrences.
References
Product Information
Format Purified
Control
  • Human kidney tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect Aldose reductase using this Anti-Aldose reductase Antibody, clone CPTC-AKR1B1-1 validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.)
Biological Information
Immunogen Full length recombinant protein corresponding to human Aldose reductase.

Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Clone CPTC-AKR1B1-1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Human
Species Reactivity Note Demonstrated to react with human.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq].
Gene Symbol
  • AR
  • ALDR1
  • ADR
  • ALR2
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

CATALYTIC ACTIVITY: Alditol + NAD(P)+ = aldose + NAD(P)H.

ENZYME REGULATION: Cys-299 may regulate the kinetic and inhibition properties of the enzyme, but does not participate in catalysis.

SUBUNIT STRUCTURE: Monomer.

SUBCELLULAR LOCATION: Cytoplasm.

TISSUE SPECIFICITY: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.

SEQUENCE SIMILARITIES: Belongs to the aldo/keto reductase family.
Molecular Weight ~39 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 0.001 µg/mL of this antibody detected Aldose reductase on 10 µg of human kidney tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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