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Anti-Prion Protein, clone 12D6.1 (mouse monoclonal)

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货号：MABN1186

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IH(P) M Purified Monoclonal Antibody
Description
Catalogue Number MABN1186
Replaces MAB1562
Description Anti-Prion Protein Antibody, clone 12D6.1
Alternate Names
  • Major prion protein
  • ASCR
  • CD230
  • PrP
  • PrP27-30
  • PrP33-35C
Background Information Major prion protein (UniProt P04156; also known as ASCR, CD230, PrP, PrP27-30, PrP33-35C) is encoded by the PRNP (also known as ALTPRP, CJD, GSD, HDL1, KURU, PRIP, PRP, SENF) gene (Gene ID 5621) in human. The major prion protein (PrP) is synthesized with an N-terminal signal peptide (a.a. 1-22) and a C-terminal proptptide (a.a. 231-253) sequence, which are posttranslationally removed to yield the mature (a.a. 23-230) N-glycosylated, glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Structurally, PrP consists of a long, disordered, flexible NH2-proximal region and a globular COOH-proximal domain linked together by a hydrophobic core (HC) region (a,a. 111-134) that is considered as a key region in both physiological and disease related processes involving the prion protein. The N-terminal region is composed of five octapeptide (PHGGGWGQ) repeats (a.a. 51-91) sandwiched between two positively charged clusters, CC1 & CC2 (a.a. 23-27 & 95-110). The exact physiological function of PrP is not known, although various biological functions have been suggested for this protein, including signal transduction, neurotransmitter metabolism, cell adhesion, antioxidant activity, neurogenesis, immune cell activation, copper metabolism and homeostasis of trace elements. Transmissible spongiform encephalopathies (TSEs) represent a family of rare and fatal neurodegenerative disorders, including Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru in human, bovine spongiform encephalopathy in cattle, and scrapie in sheep. It is widely accepted that the conformational transition of the native and predominantly α-helical cellular PrP (PrPC) to a β-sheet-rich pathogenic scrapie isoform (PrPSc) is responsible for the accumulation of PrPSc aggregates.
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Prion Protein Antibody, clone 12D6.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Prion Protein.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application Notes Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected prion protein in human cerebral cortex tissue sections.
Biological Information
Immunogen Human IgG1 Fc-tagged recombinant human prion protein internal fragment.
Epitope Internal (N-terminal half).
Clone 12D6.1
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity Clone 12D6.1 detects an epitope present in human PrP and the spliced isoform PrP(M8) reported by UniProt (P04156-1 & P04156-2), but absent in the alternative prion protein AltPrP (UniProt F7VJQ1-1).
Isotype IgG2aκ
Species Reactivity
  • Human
Species Reactivity Note Human.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PRNP
  • ALTPRP
  • CJD
  • GSD
  • HDL1
  • KURU
  • PRIP
  • PRP
  • SENF
Purification Method Protein G purified.
UniProt Number
Molecular Weight 27.66/26.89 kDa (PrP/PrP(M8) prepro-form), 22.75/25.24 kDa (mature/pro-form) calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting of recombinant human prion protein.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected 0.05 µg of human IgG1 Fc-tagged recombinant human prion protein internal fragment.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 μg
Transport Information
Supplemental Information
Specifications

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