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Anti-Excitatory amino acid transporter 2, clone G6 (mouse monoclonal)

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货号：MAB2262

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IHC, ICC M Purified Monoclonal Antibody
Description
Catalogue Number MAB2262
Description Anti-Excitatory amino acid transporter 2 Antibody, clone G6
Alternate Names
  • Glutamate/aspartate transporter II
  • Sodium-dependent glutamate/aspartate transporter 2
  • Solute carrier family 1 member 2
  • excitatory amino acid transporter 2
  • excitotoxic amino acid transporter 2
  • glial high affinity glutamate transporter
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2
  • solute carrier family 1, member 2
Background Information The activity of the main glutamate transporter in the CNS, Excitatory amino acid transporter 2 (also known as GLT1), can be regulated by protein kinase C (PKC). It is known that activation of PKC by phorbol esters promotes the clathrin-dependent internalization of the transporter, followed by its lysosomal degradation. However, the molecular mechanisms that link PKC activation and the internalization of the excitatory amino acid transporter 2 are not fully understood. The internalization process may play a role in the ubiquitylation of lysine residues located in the C-terminal tail of the excitatory amino acid transporter 2. Exposure to PMA increases the ubiquitylation of the excitatory amino acid transporter 2 in transfected cells and in the rat brain, and this ubiquitylated excitatory amino acid transporter 2 accumulates in the intracellular compartment. The activation of PKC induces the ubiquitylation of these C-terminal lysine residues in the Excitatory amino acid transporter 2 and this modification mediates the interaction of the transporter with the endocytic machinery.
References
Product Information
Format Purified
Control
  • Mouse brain tissue lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application This Anti-Excitatory amino acid transporter 2 Antibody, clone G6 is validated for use in WB, IH, IC for the detection of Excitatory amino acid transporter 2.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunocytochemistry
Application Notes Western Blot Analysis: 0.5 µg/ml from a previous lot detected Excitatory amino acid transporter 2 on 10 µg of human brain tissue lysate.
Biological Information
Immunogen Linear peptide corresponding to the C-terminus of human Excitatory amino acid transporter 2.
Epitope C-terminus
Clone G6
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes the C-terminus of Excitatory amino acid transporter 2.
Isotype IgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity Note Demonstrated to react with human and mouse. Predicted to react with rat based on 100% immunogen peptide sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Gene Symbol
  • SLC1A2
  • EAAT2
  • GLT-1
  • GLT1
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

SUBUNIT STRUCTURE: Homotrimer. Interacts with JUB By similarity.

SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

PTM: Glycosylated.

SEQUENCE SIMILARITIES: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. [View classification]
Molecular Weight 62 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected Excitatory amino acid transporter 2 on 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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