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Anti-SOX1 (chicken polyclonal)

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货号：AB5934

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, H, R WB Ch Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB5934
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Sox1 Antibody
Alternate Names
  • Transcription factor SOX-1
Background Information Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. SOX1, therefore, defines the dividing neural precursors of the embryonic central nervous system.
References
Product Information
Format Affinity Purified
Control
  • Mouse neuronal stem cell lysate
Presentation Purified chicken IgY in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
Applications
Application Detect Sox1 using this Anti-Sox1 Antibody. Validated for use in WB & IC.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to human SOX1 near the N-terminus.
Epitope Near N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Chicken
Specificity This antibody recognizes SOX1 near the N-terminus.
Species Reactivity
  • Mouse
  • Human
  • Rat
Species Reactivity Note Demonstrated to react with Mouse, Human, and Rat. Predicted to react with Rhesus Monkey based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development.
Gene Symbol
  • SOX1
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Transcriptional activator (By similarity).

SIZE: 387 amino acids; 38856 Da

SUBCELLULAR LOCATION: Nucleus (Probable).

TISSUE SPECIFICITY: Mainly in the developing central nervous system.

SIMILARITY: Contains 1 HMG box DNA-binding domain.
Molecular Weight ~39 kDa observed. An uncharacterized band may appear at ~110 kDa in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in mouse neuronal stem cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected SOX1 on 10 µg of mouse neuronal stem cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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