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Anti-hnRNP-L, clone 4D11 (mouse monoclonal)

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货号：05-1518

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, IP M Purified Monoclonal Antibody
Description
Catalogue Number 05-1518
Description Anti-hnRNP L Antibody, clone 4D11
Alternate Names
  • heterogeneous nuclear ribonucleoprotein L
Background Information Heterogeneous nuclear ribonucleoprotein L (HnRNP-L) is a polypyrimidine tract-binding protein (PTB)-binding protein and is commonly found in the nucleoplasm. HnRNP-L appears to be involved in transcription, pre-mRNA processing, mature mRNA transport to the cytoplasm, and translation. HnRNP-L binds to an RNA sequence element in a very sequence-specific manner that permit intron-independent gene expression.
References
Product Information
Format Purified
Control
  • HepG2 cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Use Anti-hnRNP L Antibody, clone 4D11 (Mouse Monoclonal Antibody) validated in WB, IP to detect hnRNP L also known as heterogeneous nuclear ribonucleoprotein L.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application Notes Immunoprecipitation:
A representative lot detected hnRNP L in IP. (Topp, J.D., et al. (2008). RNA. 14:2038–2049.)
Biological Information
Immunogen Human hnRNP proteins (from HeLa cells) purified by affinity chromatography on ssDNA agarose.
Clone 4D11
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene Symbol
  • HNRNPL
  • HNRPL
  • hnRNP L
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.

SUBUNIT STRUCTURE: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with HNRPLL.

SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

PTM: Several isoelectric forms of the L protein are probably the results of post-translational modifications.

SEQUENCE SIMILARITIES: Contains 3 RRM (RNA recognition motif) domains.

SEQUENCE CAUTION: The sequence CAA34261.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight ~64 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 0.01 µg/mL of this antibody detected hnRNP L on 10 µg of HepG2 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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