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Anti-Nuf2, clone 28-37 (mouse monoclonal)

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货号：MABE1531

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC, IP M Purified Monoclonal Antibody
Description
Catalogue Number MABE1531
Replaces 05-905
Description Anti-Nuf2 Antibody, clone 28-37
Alternate Names
  • Kinetochore protein Nuf2
  • Cell division cycle-associated protein 1
  • hNuf2
  • hNuf2R
  • hsNuf2
Background Information Kinetochore protein Nuf2 (UniProt Q9BZD4; also known as Cell division cycle-associated protein 1, hNuf2, hNuf2R, hsNuf2) is encoded by the NUF2 (also known as CDCA1, NUF2R) gene (Gene ID 83540) in human. Nuf2 is a kinetochore complex component that plays an important role in stabilizing microtubule attachment. Nuf2 knockdown results in kinetochore attachment defects and eventual death of mitotic cells. Nuf2 binds and stabilizes CENP-E in the kinetochore, and both proteins are essential for proper chromosome segregation during mitosis. Nuf2 is also shown to complex with Hec1, and the Nuf2-Hec1 complex is essential for organizing microtubule attachment sites. Nuf2 upregulation is reported in various cancers, and Nuf2 knockdown results in significant cell growth delay and apoptosis among non-small cell lung, colorectal, gastric, and ovarian cancer cell lines.
References
Product Information
Format Purified
Presentation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-Nuf2 Antibody, clone 28-37 is validated for use in Western Blotting, Immunocytochemistry, Immunoprecipitation for the detection of Nuf2.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunoprecipitation
Application Notes Immunocytochemistry Analysis: A representative lot detected Nuf2 in Nocodazole-treated HeLa cells by immunofluorescence microscopy (Stucke, V.M., et al. (2004). Chromosoma. 113(1):1-15).
Immunoprecipitation Analysis: A representative lot immunoprecipitated Nuf2 (Stucke, V.M., et al. (2004). Chromosoma. 113(1):1-15).
Biological Information
Immunogen His-tagged full-length human Nuf2.
Clone 28-37
Concentration Please refer to lot specific datasheet.
Host Mouse
Specificity The specificity of clone 28-37 was confirmed by immunoblotting, immunofluorescence microscopy, and immunoprecipitation (Stucke, V.M., et al. (2004). Chromosoma. 113(1):1-15).
Isotype IgG1κ
Species Reactivity
  • Human
Species Reactivity Note Human.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CDCA1
  • NUF2
  • NUF2R
Purification Method Protein G purified.
UniProt Number
Molecular Weight ~54 kDa observed. 54.30 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blotting in HeLa cell acid extract.

Western Blotting Analysis: A 1:125 dilution of this antibody detected Nuf2 in 10 µg of HeLa cell acid extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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