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Qiagen 凯杰 Biosharp Omega

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Rb X BACE

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货号：AB5832

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB5832
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-BACE Antibody
Alternate Names
  • ASP2
  • BACE1
  • Beta Secretase
  • beta-Site APP Cleaving Enzyme
References
Product Information
Format Purified
Presentation Purified immunoglobulin. Liquid. Buffer = PBS containing 0.02% sodium azide.
Applications
Application Anti-BACE Antibody is an antibody against BACE for use in WB.
Key Applications
  • Western Blotting
Application Notes Western blotting: 0.5-1.0 μg/mL on human brain tissue. The antibody recognizes a protein of molecular weight of 70 kDa in normal human brain lysate.

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen Synthetic peptide corresponding to amino acids 458 to 501 of human BACE (Vassar et al. 1999).
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Reacts with human BACE by Western blot.
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
Gene Symbol
  • BACE1
  • ASP2
  • beta-secretase
  • KIAA1149
  • Memapsin-2
  • BACE
  • memapsin-2
  • HSPC104
  • FLJ90568
  • EC 3.4.23.46
UniProt Number
UniProt Summary FUNCTION: SwissProt: P56817 # Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
SIZE: 501 amino acids; 55764 Da
SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Brain.
SIMILARITY: SwissProt: P56817 ## Belongs to the peptidase A1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C in undiluted aliquots for up to 6 months.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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