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anti-phospho-eIF2Be (Ser539)

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货号：07-822

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-822
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-phospho-eIF2Bε (Ser539) Antibody
References
Product Information
Format Affinity Purified
Applications
Application Anti-phospho-eIF2Bε (Ser539) Antibody is an antibody against phospho-eIF2Bε (Ser539) for use in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogen KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser539 of human eIF2Bε
Host Rabbit
Specificity Recognizes eIFB2ε phosphorylated on Ser539.
Isotype IgG
Species Reactivity
  • Human
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • EIF2B5
  • EIF-2B
  • EIF2Bepsilon
  • LVWM
  • EIF2BE
  • CLE
  • CACH
Modifications
  • Phosphorylation
Purification Method ImmunoAffinity Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q13144 # Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
SIZE: 721 amino acids; 80380 Da
SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
DISEASE: SwissProt: Q13144 # Defects in EIF2B5 are a cause of leukoencephalopathy with vanishing white matter (VWM) [MIM:603896]. VWM is a brain disease that occurs mainly in children. The neurological signs of VWM include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. Head trauma leads only to motor deterioration, whereas infections with fever may end in coma. Death occurs after a variable period of a few years to a few decades, usually following an episode of fever and coma. & Defects in EIF2B5 are a cause of ovarioleukodystrophy [MIM:603896]; also known as vanishing white matter leukodystrophy with ovarian failure. It is a condition of ovarian failure associated with cerebral abnormalities similar to those in patients with vanishing white matter leukodystrophy. & Defects in EIF2B5 are a cause of Cree leukoencephalopathy (CLE) [MIM:603896]. CLE is a rapidly fatal infantile autosomal recessive leukodystrophy that is observed in the native Cree and Chippewayan indigenous population of northern Quebec and Manitoba.
SIMILARITY: SwissProt: Q13144 ## Belongs to the EIF-2B gamma/epsilon subunits family.
Molecular Weight 82 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Routinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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