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Anti-Tyrosine Hydroxylase (rabbit polyclonal)

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货号：AB9983

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
M, R IH(P), WB Rb Purified Polyclonal Antibody
Description
Catalogue Number AB9983
Description Anti-Tyrosine Hydroxylase Antibody
Alternate Names
  • Tyrosine 3-hydroxylase
  • tyrosine 3-monooxygenase
  • tyrosine hydroxylase
Background Information Tyrosine Hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
References
Product Information
Format Purified
Control
  • Rat Brain lysate
Presentation Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3
Applications
Application Anti-Tyrosine Hydroxylase Antibody detects level of Tyrosine Hydroxylase & has been published & validated for use in IH(P) & WB.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application Notes Immunohistochemistry: 1:100 working dilutions were used on rat and mouse brain (paraffin embedded tissue).
Biological Information
Immunogen Recombinant protein
Epitope C-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity Cat. # AB9983 recognizes the C-terminus of Tyrosine Hydroxylase
Species Reactivity
  • Mouse
  • Rat
Species Reactivity Note Mouse and Rat. Reactivity with other species has not been determined.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
Gene Symbol
  • TYH
Purification Method Antigen Affinity Purified
UniProt Number
UniProt Summary FUNCTION: Plays an important role in the physiology of adrenergic neurons.
CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.
COFACTOR: Fe2+ ion.
ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity.
PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
INVOLVEMENT IN DISEASE: Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
SEQUENCE SIMILARITIES: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Molecular Weight ~ 58 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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