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Rb X Hu/Rat Cytochrome P450 Enzyme CYP2E1

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货号：AB1252

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M IHC, WB Rb Serum Polyclonal Antibody
Description
Catalogue Number AB1252
Brand Family Chemicon®
Trade Name
  • Chemicon
Description Anti-Cytochrome P450 Enzyme CYP2E1 Antibody
Alternate Names
  • cytochrome P450 2E1
  • cytochrome P450, family 2, subfamily E
  • polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • xenobiotic monooxygenase
Background Information Cytochrome P450 (CYP) is a huge and diverse superfamily of hemoproteins. It metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone.
Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions. This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. More than 7700 distinct CYP sequences are known as of September 2007.
References
Product Information
Format Serum
Control
  • Liver tissue.
Presentation Rabbit polyclonal antiserum in buffer containing no preservative.
Applications
Application Anti-Cytochrome P450 Enzyme CYP2E1 Antibody is an antibody against Cytochrome P450 Enzyme CYP2E1 for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application Notes Immunohistochemistry:
A previous lot was used on formaldehyde treated and frozen sections.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen Synthetic peptide.
Host Rabbit
Specificity Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes in these species.
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Gene Symbol
  • CYP2E1
  • OTTHUMP00000046571
  • CYPIIE1
  • CYP2E
  • P450C2E
  • P450-J
  • CPE1
Purification Method Unpurified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs to the cytochrome P450 family.
Molecular Weight 57 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot on Human brain lysates.

Western Blot Analysis:
1:1000 dilution of this antibody detected Cytochrome P450 CYP2E1 on 10 μg of Human brain lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at -20°C in undiluted aliquots from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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