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Anti-Osteopontin, clone 6B6.2 (mouse monoclonal)

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货号：04-970

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB M Purified Monoclonal Antibody
Description
Catalogue Number 04-970
Description Anti-Osteopontin Antibody, clone 6B6.2
Alternate Names
  • Bone sialoprotein 1
  • SPP1/CALPHA1 fusion
  • Urinary stone protein
  • bone sialoprotein I
  • osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
  • secreted phosphoprotein 1
  • secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
  • secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
  • Uropontin
  • osteopontin
Background Information Osteopontin is a single-chain polypeptide. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of osteopontin in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in osteopontin "knockout" mice has not established a definitive role for osteopontin in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of osteopontin to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity.
References
Product Information
Format Purified
Control
  • Human serum lysate
Presentation Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application Anti-Osteopontin Antibody, clone 6B6.2 detects level of Osteopontin & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Application Notes Western Blot Analysis: 0.5 µg/mL from a representative lot detected Osteopontin on 10 µg of mouse kidney lysate.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of human Osteopontin.
Epitope C-terminus
Clone 6B6.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes Osteopontin at the C-terminus.
Isotype IgMκ
Species Reactivity
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BNSP
  • BSPI
  • ETA-1
  • Nephropontin
  • OPN
  • SPP-1
Purification Method Ion Exchange
UniProt Number
UniProt Summary FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).

SUBUNIT STRUCTURE: Ligand for integrin alpha-V/beta-3.

SUBCELLULAR LOCATION: Secreted.

PTM: Extensively phosphorylated on clustered serine residues.

N- and O-glycosylated.

DISEASE: This protein plays a principal role in urinary stone formation as the stone matrix.

SEQUENCE SIMILARITY: Belongs to the osteopontin family.
Molecular Weight ~70 kDa observed. The calculated molecular weight of this protein is ~35 kDa but it is has extensive post transitional modifications and runs at ~70 kDa. (Adhikari, N., et al. (2010). Arterioscler Thromb Vasc Biol. 31(1):86-94.)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human serum lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Osteopontin on 10 µg of human serum lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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