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Anti-LDLR, clone C7 (mouse monoclonal)

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货号：MABS26

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, B WB M Purified Monoclonal Antibody
Description
Catalogue Number MABS26
Description Anti-LDLR Antibody, clone C7
Alternate Names
  • low density lipoprotein receptor
  • LDL receptor
Background Information Low-Density Lipoprotein (LDL) Receptor is a mosaic protein that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). Mutations in LDLR are associated with familial hypercholesterolemia which is characterized by high levels of LDL in the blood.
References
Product Information
Format Purified
Control
  • ARPE-19 cell lysate
Presentation Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Anti-LDLR Antibody, clone C7 is validated for use in WB for the detection of LDLR.
Key Applications
  • Western Blotting
Biological Information
Immunogen Partially purified bovine adrenal LDL receptor
Clone C7
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Specificity This antibody recognizes LDLR.
Isotype IgG2bκ
Species Reactivity
  • Human
  • Bovine
Species Reactivity Note Demonstrated to react with human. Predicted to react with bovine based on 100% sequence homology.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq].
Gene Symbol
  • LDLR
  • LDLCQ2
  • FH
  • FHC
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: SwissProt: P01130 # Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.

SIZE: 860 amino acids; 95376 Da

SUBUNIT: Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

PTM: N- and O-glycosylated.

DISEASE: SwissProt: P01130 # Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).

SIMILARITY: SwissProt: P01130 ## Belongs to the LDLR family. & Contains 3 EGF-like domains. & Contains 7 LDL-receptor class A domains. & Contains 6 LDL-receptor class B repeats.
Molecular Weight 160 kDa Observed The translation of LDLR mRNA yields a 120 kDa protein that is post-translationally modified in the Golgi apparatus into the mature, 160 kDa LDLR. (Tolleshaug, H., et al. (1982). Cell 30:715–724.)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in ARPE-19 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LDLR on 10 µg of ARPE-19 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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