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Anti-ATG7 (rabbit polyclonal)

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货号：AB10511

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Rhesus Macaque WB, IHC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB10511
Replaces 04-1055
Description Anti-ATG7 Antibody
Alternate Names
  • APG7 autophagy 7-like
  • APG7 autophagy 7-like (S. cerevisiae)
  • ATG7 autophagy related 7 homolog (S. cerevisiae)
  • Ubiquitin-activating enzyme E1-like protein
  • ubiquitin activating enzyme E1-like protein
Background Information Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved in development, differentiation, growth regulation, and tissue remodeling in multicellular organisms. Autophagy-related protein 7 (ATG7) is an ubiquitin-like modifier-activating enzyme and is essential for multisubstrates such as ATG8-like proteins GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A. ATG 7 is also involved in ATG12 conjugation to ATG5 and ATG3. In this interaction, an ATG7-ATG3 complex plays a role in the conjugation of ATG12 to ATG5. Recently, ATG7 deficiency has been linked to human breast cancer resistance to anti-cancer therapies.
References
Product Information
Format Affinity Purified
Control
  • Human lymph node tissue lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-ATG7 Antibody detects level of ATG7 & has been published & validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected ATG7 in vascular and high grade prostate carcinoma tissues.
Biological Information
Immunogen KLH-conjugated linear peptide corresponding to the N-terminus of human ATG7.
Epitope N-terminus
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity This antibody recognizes ATG7 at the N-terminus.
Species Reactivity
  • Human
  • Rhesus Macaque
Species Reactivity Note Demonstrated to react with human.
Predicted to react with rhesus macaque, orangutan, bovine, canine, and yeast based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq].
Gene Symbol
  • APG7-LIKE
  • APG7-like
  • APG7L
  • GSA7
  • hAGP7
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy By similarity.

SUBUNIT STRUCTURE:Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.

SUBCELLULAR LOCATION: Cytoplasm Probable.

TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Ref.4

DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity).

SEQUENCE SIMILARITY: Belongs to the ATG7 family.
Molecular Weight ~75 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in human lymph node tissue lysate.

Western Blot Analysis: 5 µg/mL of this antibody detected ATG7 in 10 µg of human lymph node tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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