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Anti-F-actin-capping protein subunit alpha-1 (rabbit polyclonal)

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货号：AB6016

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Pm, Rhesus Macaque, B, Po, Ca WB, ICC Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number AB6016
Description Anti-F-actin-capping protein subunit alpha-1 Antibody
Alternate Names
  • capping protein (actin filament) muscle Z-line, alpha 1
  • CapZ alpha-1
  • F-actin-capping protein subunit alpha-1
Background Information F-actin capping protein subunit alpha (CapZ alpha) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of an α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. CapZ is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of CapZ’s subunits. All three alpha subunit isoforms are components of the WASH complex. Little is known about isoforms 1 and 2; however, isoform 3 is thought to be involved in spermatid morphogenesis and is exclusively observed within sperm and testis, with highest expression within the neck region of sperm.
References
Product Information
Format Affinity Purified
Control
  • HeLa cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Detect F-actin-capping protein subunit alpha-1 using this Anti-F-actin-capping protein subunit alpha-1 Antibody validated for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application Notes Western Blot (Snap i.d.®) Analysis: 1 µg/mL from a previous lot detected F-actin-capping protein subunit alpha-1 on 10 µg of HeLa cell lysate.
Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected F-actin-capping protein subunit alpha-1 in NIH/3T3, HeLa, and A431 cells.
Biological Information
Immunogen GST-tagged recombinant protein corres-ponding to human F-actin-capping protein subunit alpha-1.
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Primate
  • Rhesus Macaque
  • Bovine
  • Pig
  • Canine
Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with rhesus macaque, primate, bovine, porcine, and canine based on 100% sequence homology.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CAPPA1
  • CAPZ
  • Cap Z
  • CAZ1
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Interacts with S100A By similarity. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts with S100B.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton By similarity.
SEQUENCE SIMILARITIES: Belongs to the F-actin-capping protein alpha subunit family.
Molecular Weight ~35 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected F-actin-capping protein subunit alpha-1 on 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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