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Anti-Plexin B3, clone 17H10.1 (mouse monoclonal)

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货号：MAB10424

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB10424
Description Anti-Plexin B3 Antibody, clone 17H10.1
Alternate Names
  • plexin B3
  • plexin-B3
  • plexin 6
Background Information Plexin-B3 is a member of the plexin-B family of semaphorin receptors. The plexin-B family of receptors may be especially important in axonal guidance during nervous system development. Plexin-B3 is thought to play an intricate and non-redundant role in this development. It is a specific receptor for Semaphorin-5A (Sema5A), whose activation by Sema5A mediates functional responses in Plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). Recently, Plexin-B3 has been described as a potent stimulator of neurite outgrowth, making it an intriguing research target for traits related to human brain development and cerebral connectivity.
References
Product Information
Format Purified
Control
  • Normal rat brain tissue
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Plexin B3 Antibody, clone 17H10.1 is an antibody against Plexin B3 for use in IH.
Key Applications
  • Immunohistochemistry
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human Plexin-B3.
Clone 17H10.1
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Rat
Species Reactivity Note Demonstrated to react with rat. Expected to react with human based on immunogen design.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene Symbol
  • PLXN6
  • PLEXB3
  • PLEXR
  • PLXNB3
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration.

SUBUNIT STRUCTURE: Binds MET and MST1R.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein

TISSUE SPECIFICTY: Detected at very low levels in several fetal tissues.

SEQUENCE SIMLARITIES: Belongs to the plexin family.

Contains 4 IPT/TIG domains.

Contains 1 Sema domain.

SEQUENCE CAUTION: The sequence BAA86520.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight 206 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in normal rat brain tissue.

Immunohistochemistry Analysis: 1:50 dilution of this antibody detected Plexin B3 in normal rat brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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