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Anti-human Tks4 (rabbit polyclonal)

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货号：09-267

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M WB, IP Rb Purified Polyclonal Antibody
Description
Catalogue Number 09-267
Description Anti-human Tks4 Antibody
Alternate Names
  • Adapter protein HOFI
  • Factor for adipocyte differentiation 49
  • SH3 and PX domains 2B
  • adaptor protein HOFI
Background Information Tks4 (gene symbol SH3PXD2B) is a novel adaptor protein; also known as SH3 and PX domain-containing protein 2B, (Courtneidge, 2005). It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). Additionally, Tks4 may be involved in the recruitment of MT1-MMP and ECM degradation.
Tks4 is broadly expressed and localizes in the cytoplasm of the podosome.
References
Product Information
Format Purified
Control
  • NIH3T3 cell lysate.
Presentation Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3.
Applications
Application This Anti-human Tks4 Antibody is validated for use in WB, IP for the detection of human Tks4.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Biological Information
Immunogen Recombinant protein containing amino acids 431-595 of human Tks4.
Epitope a. a. 431-595
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Rabbit
Specificity The antibody recognizes human Tks4.
Species Reactivity
  • Human
  • Mouse
Species Reactivity Note Human and mouse (76% homology). Predicted to cross react with rat (77% homology). Reactivity with other species has not been tested.
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FAD49
  • FLJ20831
  • HOFI
  • KIAA1295
Purification Method Protein A Purfied
UniProt Number
UniProt Summary FUNCTION: Binds a range of phosphoinositides including phosphatidylinositol 3,5-biphosphate and, to a lesser extent, phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 5-biphosphate. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation By similarity.
SUBCELLULAR LOCATION: Cytoplasm By similarity.
DOMAIN: The PX domain is required for binding phosphoinositides and can also bind to the third SH3 domain By similarity.
SEQUENCE SIMILARITIES: Belongs to the SH3PXD2 family.
Contains 1 PX (phox homology) domain.
Contains 4 SH3 domains.
Molecular Weight ~ 130 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated on a representative lot by Immunoprecipitation followed by Western blot on NIH3T3 cell lysate using Anti-human Tks4.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Maintain at 2-8°C for up to 1 year from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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