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Anti-Interleukin-17 (IL-17), clone 1C12 (mouse monoclonal)

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货号：MABF12

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB M Purified Monoclonal Antibody
Description
Catalogue Number MABF12
Replaces 04-464
Description Anti-Interleukin-17 (IL-17) Antibody, clone 1C12
Alternate Names
  • interleukin 17A
  • interleukin-17A
  • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
  • cytotoxic T-lymphocyte-associated serine esterase 8
  • Cytotoxic T-lymphocyte-associated antigen 8
  • cytotoxic T-lymphocyte-associated protein 8
Background Information Interleukin-17 (IL-17) is known to stimulate the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase. TRAF6 is essential in the IL-17 signaling pathway of proinflammatory response. Over-expression of IL-17 by T cells seems to be important in systemic sclerosis pathogenesis. IL-17 is particularly involved in early development of the disease by activating fibroblast propagation and creation of IL-1. IL-17 connects lymphoid and myeloid host defenses and so plays an essential part in the microbial defense response. IL-17 also seems to support the innate immune response by mobilizing neutrophils. IL-17 may be an important clinical target for allergic airway disease.
References
Product Information
Format Purified
Control
  • Human IL-17 recombinant protein.
Presentation Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Interleukin-17 (IL-17) Antibody, clone 1C12 is an antibody against Interleukin-17 (IL-17) for use in WB.
Key Applications
  • Western Blotting
Application Notes ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX).
Biological Information
Immunogen Cohesin-tagged recombinant protein corresponding to human IL-17.
Clone AB44.57.27E4.1C12
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG2aκ
Species Reactivity
  • Human
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq].
Gene Symbol
  • IL17A
  • CTLA8
  • IL-17
  • IL17
  • IL-17A
  • CTLA-8
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

SUBUNIT STRUCTURE: Homodimer.

SUBCELLULAR LOCATION: Secreted.

TISSUE SPECIFICITY: Restricted to activated memory T-cells.

PTM: Found both in glycosylated and nonglycosylated forms.

SEQUENCE SIMILARITIES: Belongs to the IL-17 family.
Molecular Weight ~15 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in lysate from cells expressing human IL-17 recombinant protein.

Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-17 recombinant protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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