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Anti-Daxx

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货号：04-445

品牌：Millipore 密理博

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Replacement Information

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, Ht, M, R IP, WB, ICC Rb Serum Polyclonal Antibody
Description
Catalogue Number 07-471
Replaces 04-445
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Daxx Antibody
References
Product Information
Format Serum
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
Application Anti-Daxx Antibody is an antibody against Daxx for use in IP, WB & IC.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
Immunogen GST fusion protein corresponding to residues 472-740 of human Daxx.
Host Rabbit
Specificity Daxx
Isotype IgG
Species Reactivity
  • Human
  • Hamster
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • DAXX
  • MGC126246
  • Daxx
  • BING2
  • hDaxx
  • MGC126245
  • EAP1
  • DAP6
Purification Method Antiserum
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q9UER7 # Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
SIZE: 740 amino acids; 81373 Da
SUBUNIT: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By similarity). The non-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress.TISSUE SPECIFICITY: Ubiquitous.
PTM: Sumoylated. & Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by HIPK1 upon glucose deprivation. & Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation.
SIMILARITY: SwissProt: Q9UER7 ## Belongs to the DAXX family.
Molecular Weight 110 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot in HeLa nuclear extract
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 200 µL
Transport Information
Supplemental Information
Specifications

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