Anti-human CD151 clone TS151 (mouse monoclonal)

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Anti-human CD151 clone TS151 (mouse monoclonal)

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货号：MABT59

品牌：Millipore 密理博

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	FC, IP	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABT59
Description	Anti-human CD151 clone TS151 Antibody
Alternate Names	CD151 molecule (Raph blood group) CD151 antigen hemidesmosomal tetraspanin CD151 platelet-endothelial cell tetraspan antigen 3 CD151 antigen (Raph blood group) tetraspanin-24 platelet surface glycoprotein gp27 Membrane glycoprotein SFA-1 Platelet-endothelial tetraspan antigen 3 Tetraspanin-24
Background Information	CD151 is a tetraspanin and is thought to aid in the creation of multi-protein complexes at the surface of cells. CD151 forms secure laminin-binding compounds in the kidney, using integrins alpha3beta1 and alpha6beta1, and in the skin, using alpha3beta1 and alpha6beta4. CD151 may also play an important role in the inner ear and may also be involved in erythropoiesis. CD151 may be an important marker for prostate cancer and the higher the level of CD151, the less likely the patient survives. Research has shown that mice lacking CD151 have a damaged re-epithelialization process and lack wound healing ability.

References

Product Information
Format	Purified
Control	HeLa cells
Presentation	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Applications
Application	Anti-human CD151 clone TS151 Antibody detects level of human CD151 clone TS151 & has been published & validated for use in FC & IP.
Key Applications	Flow Cytometry Immunoprecipitation
Application Notes	Immunoprecipitation Analysis: A previous lot was used by an independent laboratory to immunoprecipitate CD151 from a Brij97 lysate of HeLa cells (Charrin, S., et al. (2001). The Biological journal of Chemistry. 276(17):14329–14337) and a Brij97 lysate of Daudi cells transfected with integrin alpha3beta1 (Charrin, S., et al. (2003). Biochemical and Biophysical Research Communications 304:107–112).

Biological Information
Immunogen	Whole HeLa cells
Clone	TS151
Host	Mouse
Isotype	IgG1κ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001034579
Entrez Gene Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq].
Gene Symbol	CD151 SFA1 SFA-1 TSPAN24 PETA-3 RAPH tspan-24 Tspan-24 GP27 MER2 PETA3
Purification Method	Protein G Purified
UniProt Number	P48509
UniProt Summary	FUNCTION: Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. SUBUNIT STRUCTURE: Interacts with integrins alpha3beta1, alpha5beta1, alpha3beta1 and alpha6beta4, with CD9 and CD181. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICTY: Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. INDUCTION: By HTLV-1. POLYMORPHISM: CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative. IINVOLVEMENT IN DISEASE: Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]. NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. SEQUENCE SIMILARITIES: Belongs to the tetraspanin (TM4SF) family.
Molecular Weight	28 kDa calculated

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Flow Cytometry in HeLa cells. Flow Cytometry Analysis: A 1:100 dilution of this antibody detected CD151 in HeLa cells.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

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Anti-human CD151 clone TS151 (mouse monoclonal)

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