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Anti-Nck (rabbit polyclonal IgG)

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货号：06-288

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M, R IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 06-288
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-Nck Antibody
References
Product Information
Format Purified
Presentation 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
Applications
Application Detect Nck using this Anti-Nck Antibody validated for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen Purified GST fusion protein produced in E. coli., corresponding to human Nck amino acid sequence 1 to 254
Host Rabbit
Specificity Nck
Isotype IgG
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS.
Gene Symbol
  • NCK1
  • MGC12668
  • NCK
  • NCKalpha
Purification Method Protein G Chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: P16333 # Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates.
SIZE: 377 amino acids; 42864 Da
SUBUNIT: Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Phosphorylated on Ser and Tyr residues.
SIMILARITY: SwissProt: P16333 ## Contains 1 SH2 domain. & Contains 3 SH3 domains.
Molecular Weight 47kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on human A431 carcinoma cells, mouse 3T3/A31 fibroblasts or rat L6 skeletal fibroblasts
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 2 years at -20°C
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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