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Anti-Serine/threonine-protein kinase 39 (rabbit polyclonal)

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货号：07-2271

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H WB Rb Affinity Purified Polyclonal Antibody
Description
Catalogue Number 07-2271
Description Anti-Serine/threonine-protein kinase 39 Antibody
Alternate Names
  • serine threonine kinase 39
  • proline-alanine-rich STE20-related kinase
  • Serine/threonine-protein kinase 39
  • serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
  • Ste-20-related kinase
  • Ste20-like protein kinase
  • small intestine SPAK-like kinase
  • STE20/SPS1-related proline-alanine-rich protein kinase
  • STE20/SPS1 homolog
  • Serine/threonine-protein kinase 39
  • serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
  • Ste-20-related kinase
  • Ste20-like protein kinase
  • small intestine SPAK-like kinase
  • STE20/SPS1-related proline-alanine-rich protein kinase
  • STE20/SPS1 homolog
Background Information STE20/SPS-1 related proline alanine-rich kinase (SPAK), or commonly known as Serine/threonine-protein kinase 39, is a member of the SPS1 subfamily of STE20 kinases. Serine/threonine-protein kinase 39 is also very highly conserved between species and has been shown to activate the p38 pathways. Serine/threonine-protein kinase 39 also has a caspase cleavage site and these two functions may mean that Serine/threonine-protein kinase 39 plays a role in stress-activated signaling. Serine/threonine-protein kinase 39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not posses this ability. Recent research has also made a connection between Serine/threonine-protein kinase 39 and regulation of blood pressure.
References
Product Information
Format Affinity Purified
Control
  • HEK293 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application This Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.
Key Applications
  • Western Blotting
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human Serine/threonine-protein kinase 39.
Host Rabbit
Species Reactivity
  • Human
Species Reactivity Note Demonstrated to react with human.
Other homologies: Mouse (95% sequence homology). Rat (94% sequence homology).
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq].
Gene Symbol
  • PASK
  • SPAK
  • DCHT
  • SPAK
Purification Method Affinity Purfied
UniProt Number
UniProt Summary FUNCTION: May act as a mediator of stress-activated signals.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBCELLULAR LOCATION: Cytoplasm Probable. Nucleus Probable. Note: Nucleus when caspase-cleaved Probable.

TISSUE SPECIFICTY: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

DOMAIN: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.

SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Contains 1 protein kinase domain.
Molecular Weight ~60 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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