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Anti-Plexin-A3, clone 18A9.2 (mouse monoclonal)

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货号：MAB10422

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
R, H, M WB, IHC M Purified Monoclonal Antibody
Description
Catalogue Number MAB10422
Description Anti-Plexin-A3 Antibody, clone 18A9.2
Alternate Names
  • plexin A3
  • PLEXIN-A3
  • plexin-A3
  • Sex chromosome X transmembrane protein of HGF receptor family 3
  • Semaphorin receptor SEX
  • plexin-4
  • Plexin-4
Background Information Plexin-A3 is a cell surface receptor for semaphorin that controls signaling for neuronal axon regulation. Plexin-A3 is thought to play a role in Sema3F and Sema3A signaling, has been described as essential for dorsal turning of the corticospinal tract axons and may be an important contributor to development of hippocampal axonal projections. Plexin-A3 has been found expressed in newly-differentiated sympathetic neurons, but not their neural crest precursors, and together with Plexin-A4, functions cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons.
References
Product Information
Format Purified
Control
  • PC-12 cell lysate
Presentation Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-Plexin-A3 Antibody, clone 18A9.2 is a Mouse Monoclonal Antibody for detection of Plexin-A3 also known as PLEXIN-A3, Semaphorin receptor SEX or Plexin-4 & has been validated in WB & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application Notes Western Blot Analysis: 1 µg/mL from a previous lot detected Plexin-A3 on 10 µg of HT-29 and NIH/3T3 cell lysates.

Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Plexin-A3 in colorectal carcinoma tissue.
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human Plexin-A3.
Clone 18A9.2
Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
Host Mouse
Isotype IgG1κ
Species Reactivity
  • Rat
  • Human
  • Mouse
Antibody Type Monoclonal Antibody
Entrez Gene Number
Entrez Gene Summary The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq].
Gene Symbol
  • HSSEXGENE
  • SEX
  • XAP-6
  • PLXN3
  • PLXN4
  • Plxn3
  • PLXNA3
Purification Method Protein G
UniProt Number
UniProt Summary FUNCTION: Putative receptor involved in the development of neural and epithelial tissues.

SUBCELLUALR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

TISSUE SPECIFICTY: Predominant in neural tissue during development (By similarity); widely expressed in adult tissue.

SEQUENCE SIMILARITIES: Belongs to the plexin family.

Contains 4 IPT/TIG domains.

Contains 1 Sema domain.
Molecular Weight ~220 kDa observed. The calculated molecular weight of this protein is 208 kDa; however, a higher band may be observed due to glycosolation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Plexin-A3 on 10 µg of PC-12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µg
Transport Information
Supplemental Information
Specifications

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