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Anti-Insulin, clone CE9H9 (mouse monoclonal)

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货号：05-1107

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, B, Rb, Po, Sh, Gp, Ch, F IH(P) M Unpurified Monoclonal Antibody
Description
Catalogue Number 05-1107
Replaces MAB10218
Description Anti-Insulin Antibody, clone CE9H9
Background Information Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
References
Product Information
Format Unpurified
Control
  • Human pancreas tissue.
Presentation Unpurified mouse monoclonal as liquid ascites fluid containing no preservatives.
Applications
Application Detect Insulin using this Anti-Insulin Antibody, clone CE9H9 validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
Immunogen Zinc containing crystalline human insulin
Clone CE9H9
Host Mouse
Specificity The antibody binds to insulin from human, cow, pig and rabbit and to pro-insulin from cow and pig.
Isotype IgG1
Species Reactivity
  • Human
  • Bovine
  • Rabbit
  • Pig
  • Sheep
  • Guinea Pig
  • Chicken
  • Fish
Species Reactivity Note Proven to react with human, bovine, pig, rabbit, sheep and guinea pig.
Antibody Type Monoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ILPR
  • IRDN
  • OTTHUMP00000011161
  • OTTHUMP00000011162
  • OTTHUMP00000196038
  • insulin
  • proinsulin
Purification Method Unpurified ascites
UniProt Number
UniProt Summary FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular Weight ~12 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Immunohistochemistry in human pancreas tissue.
IHC Analysis: A 1.25 µg/mL dilution of this antibody detected insulin in human pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions 1 year at -20°C from date of receipt
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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