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Rb X NMDAR2B phospho Tyrosine1336

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货号：AB9690

品牌：Millipore 密理博

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北京朝阳

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EA (预计3-5工作日到货)

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
R	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	AB9690
Replaces	07-533
Brand Family	Chemicon®
Trade Name	Chemicon
Description	Anti-NMDAR2B phospho Tyrosine 1336 Antibody
Alternate Names	NR2B

References

Product Information
Format	Affinity Purified
Presentation	Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Applications
Application	Detect NMDAR2B phospho Tyrosine 1336 using this Anti-NMDAR2B phospho Tyrosine 1336 Antibody validated for use in WB.
Key Applications	Western Blotting
Application Notes	Western blot: 1:1,000. Optimal working dilutions must be determined by the end user.

Biological Information
Immunogen	Synthetic peptide of amino acids surrounding the phosphoTyrosine 1336 site of rat NMDAR2B. The immunogen has 100% similarity with human and mouse.
Host	Rabbit
Specificity	NMDAR2B, phosphoTyrosine1336. The antibody recognizes a protein of ~180 kDa corresponding to NMDAR2B, phosphoTyrosine1336 in lysates from rat brain hippocampus. Immunolabeling is blocked by the phosphopeptide used as the immunogen but not the corresponding non-phosphopeptide. Immunolabeling is also blocked by l-phosphatase treatment.
Species Reactivity	Rat
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NM_000834.2
Entrez Gene Summary	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
Gene Symbol	GRIN2B MGC142180 Glutamate NMDAR2B NR3 NR2B MGC142178 hNR3
Modifications	Phosphorylation
UniProt Number	Q13224
UniProt Summary	FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. SIZE: 1484 amino acids; 166367 Da SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

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Product Usage Statements
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Packaging Information
Material Size	100 µL

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