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Anti-BAF180 (rabbit polyclonal)

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货号：ABE70

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB, ChIP Rb Purified Polyclonal Antibody
Description
Catalogue Number ABE70
Description Anti-BAF180 Antibody
Alternate Names
  • polybromo 1
  • protein polybromo-1
  • BRG1-associated factor 180
  • polybromo-1D
  • Polybromo-1D
Background Information BRG1-associated factor 180 (BAF180) is a subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex, and is known to contain 6 bromo domains, 2 BAH domains, and a single HMG box DNA-binding domain. BAF180 has a critical and active role in the transcriptional activation and repression of specific genes via chromatin remodeling, including genes involved in the development of the heart, thus suggesting a role in mammalian development. Recent studies demonstrate BAF180 to suppress tumorigenesis through its ability to regulate both baseline and signal-dependent p21 transcription by its binding of the p21 promoter. Expression of BAF180 is reported in a wide range of tissues.
References
Product Information
Format Purified
Control
  • HEK293 cell lysate
Presentation Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application Anti-BAF180 Antibody is a Rabbit Polyclonal Antibody for detection of BAF180 also known as protein polybromo-1, BRG1-associated factor 180 & has been validated in WB.
Key Applications
  • Western Blotting
  • Chromatin Immunoprecipitation (ChIP)
Application Notes Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in ChIP (Xia, W., et al. (2008).
Biological Information
Immunogen GST-tagged recombinant protein corresponding to human BAF180.
Host Rabbit
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PB1
  • BAF180
  • PBRM1
  • hPB1
Purification Method Protein G Purified
UniProt Number
UniProt Summary FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).

SUBUNIT STRUCTURE: Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Interacts with PHF10/BAF45A (By similarity).

SUBCELLULAR LOCATION: Nucleus.

TISSUE SPECIFICTY: Widely expressed.

PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

SEQUENCE SIMILARITIES: Contains 2 BAH domains.

Contains 6 bromo domains.

Contains 1 HMG box DNA-binding domain.

SEQUENCE CAUTION: The sequence AAI15010.1 differs from that shown. Reason: Contaminating sequence.

The sequence AAI15011.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI15012.1 differs from that shown. Reason: Erroneous termination at position 78. Translated as Arg.

The sequence BAB71210.1 differs from that shown. Reason: Erroneous initiation.
Molecular Weight ~193 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance Evaluated by Western Blot in HEK293 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected BAF180 in 10 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 100 µL
Transport Information
Supplemental Information
Specifications

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