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Anti-SOS 1, CT (rabbit polyclonal IgG)

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货号：07-337

品牌：Millipore 密理博

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重要规格表

Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rb Purified Polyclonal Antibody
Description
Catalogue Number 07-337
Brand Family Upstate
Trade Name
  • Upstate
Description Anti-SOS1 Antibody, CT
References
Product Information
Format Purified
Presentation Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
Applications
Application Anti-SOS1 Antibody, CT is an antibody against SOS1 for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Biological Information
Immunogen peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1)
Host Rabbit
Specificity SOS1
Isotype IgG
Species Reactivity
  • Human
  • Mouse
Antibody Type Polyclonal Antibody
Entrez Gene Number
Entrez Gene Summary This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4.
Gene Symbol
  • SOS1
  • NS4
  • SOS-1
  • GF1
  • HGF
  • GGF1
  • GINGF
Purification Method Protein A chromatography
UniProt Number
UniProt Summary FUNCTION: SwissProt: Q07889 # Promotes the exchange of Ras-bound GDP by GTP.
SIZE: 1333 amino acids; 152464 Da
SUBUNIT: Interacts with GRB2. Interacts with phosphorylated LAT2.
TISSUE SPECIFICITY: Expressed in gingival tissues.
DISEASE: SwissProt: Q07889 # Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also designated GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. & Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common.
SIMILARITY: SwissProt: Q07889 ## Contains 1 DH (DBL-homology) domain. & Contains 1 N-terminal Ras-GEF domain. & Contains 1 PH domain. & Contains 1 Ras-GEF domain.
Molecular Weight 175 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size 200 µg
Transport Information
Supplemental Information
Specifications

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